Graduate

BME 201 Scientific Writing

Covers effective writing styles for scientific communication for bio-science and engineering graduate students. Covers instruction for writing grant applications, scientific manuscripts, and thesis proposals. Students practice by preparing, editing, and evaluating each of these documents.

Credits

3

Instructor

,

Requirements

Enrollment is restricted to graduate students.

BME 205 Bioinformatics Models and Algorithms

Covers bioinformatics models and algorithms: the use of computational techniques to convert the masses of information from biochemical experiments (DNA sequencing, DNA chips, and other high-throughput experimental methods) into useful information. Emphasis is on DNA and protein sequence alignment and analysis.

Credits

5

Instructor

, ,

Requirements

Enrollment is restricted to graduate students. Undergraduates may enroll with prerequisite(s): BME 160; and CSE 107 or STAT 131; and concurrent enrollment in BIOC 100A.

BME 215 Applied Gene Technology

Detailed insight into the techniques and technological trends in genomics and transcriptomics, building the necessary foundations for further research in genetic association studies, population genetic association studies, population genetics, diagnostics, medicine, and drug development. Students should already have a deeper understanding of the basic tools of molecular biotechnology than acquired in introductory courses in biotechnology, biochemistry, and molecular biotechnology.

Credits

5

Instructor

Requirements

Enrollment is restricted to graduate students.

BME 218 Mathematics of the Mind

Investigates the mind as an adaptive system, the evolutionary history of the brain, and mathematical theories of knowledge representation and learning in humans and machines. Students build Jupyter notebooks that interact with human cerebral cortex organoids to explore adaptive processes in neural circuits. Taught in conjunction with BME 118. Students cannot receive credit for this course and BME 118.

Credits

5

Instructor

Requirements

Enrollment is restricted to graduate students. Students should have knowledge of calculus, linear algebra, and Python programming.

BME 229 Protein and Cell Engineering

Focuses on established and novel strategies for protein and cell engineering. Explores concepts, design, and practical applications of engineered proteins, cells, and organisms as research tools and in therapeutic applications. Recommended for graduate students with interests in bioengineering.

Credits

5

Instructor

,

Requirements

Enrollment is restricted to graduate students. Undergraduates by permission of instructor.

BME 230A Introduction to Computational Genomics and Systems Biology

Introductory and intermediate-level topics in computational genomics, DNA and RNA sequence analysis, mapping, quantification, detection of variants and their associations with disease. Covers topics in machine-learning, probabilistic graphical models, gene regulatory network inference, and single cell analysis. Students conduct related independent research.

Credits

5

Instructor

Requirements

Prerequisite(s): BME 205. Enrollment is restricted to juniors, seniors, and graduate students.

BME 230B Advanced Computational Genomics and Systems Biology

Covers advanced topics in computational genomics, DNA and RNA sequence analysis, mapping, quantification, detection of variants and their associations with disease. Topics include machine-learning, probabilistic graphical models, gene regulatory network inference, and single cell analysis. Students participate in teams in a computational analysis competition.

Credits

5

Requirements

Prerequisite(s): BME 230A. Enrollment is restricted to juniors, seniors, and graduate students.

BME 232 Evolutionary Genomics

Covers major recent advances in evolutionary genomics. Students learn to analyze and interpret scientific writing in depth. Students also present on work covered in the class and produce one research or review paper. Students may not receive credit for this course and course 132.

Credits

5

Requirements

Enrollment is restricted to graduate students. BME 105 or BIOL 105 or equivalent courses in higher-level genetic processes are highly recommended.

BME 237 Applied RNA Bioinformatics

Teaches methods for RNA gene discovery; gene expression quantification; probabalistic modeling, secondary structure/trans-interaction prediction; mRNA splicing; and functional analysis. Emphasis on leveraging comparative genomics and employing high-throughput RNA sequencing data. Includes lectures, scientific literature discussion, problem sets, and final gene-discovery project.

Credits

5

Requirements

Enrollment is restricted to seniors and graduate students.

BME 263 Applied Visualization and Analysis of Scientific Data

Python and its Numpy, Scipy, and Matplotlib packages as well as Inkscape are used to generate publication quality figures from scientific data. Students cannot receive credit for this course and course 163.

Credits

5

Requirements

Prerequisite(s): BME 160 or BME 205. Prerequisite(s) can be waived in cases where students have required programming skills. Enrollment is restricted to graduate students.

BME 272 Precision Medicine

Focuses on modern "precision" approaches to understanding human health, where every patient is unique. Explores basic and clinical discoveries and 'omics-based medicine for the prevention, diagnosis, and treatment of disease. Emphasis is on genomic approaches and applications to cancer.

Credits

5

Requirements

Enrollment restricted to juniors, seniors, and graduate students.

BME 273 Stem Cell Epi/Genomics

Course focuses on the application of epi/genomic technologies of stem cells. Topics include 'omics to interrogate pluripotency, cell lineages, hierarchies, trajectories, epigenomic reprogramming. Class includes hands-on computational analysis of epi/genomics data. For graduate/postdoctoral trainees engaged in stem cell research. Enrollment is restricted to graduate students and by permission of the instructor. Basic programming knowledge is recommended.

Credits

3

BME 275 Entrepreneurship in Biotechnology

Focuses on contemporary issues in commercializing biotechnology and genomics, emphasizing development of teamwork and communication skills. Topics include intellectual property management, fundraising, market analysis, and technology development as related to biotechnology start-ups. Students perform real-world tasks preparing for commercialization. Taught in conjunction with Biomolecular Engineering 175.

Credits

5

BME 278 Stem Cell Biology

Basic stem cell concepts, experimental approaches, and therapeutic potential are discussed. Students gain experience in reading and critically evaluating the primary scientific literature. Students cannot receive credit for this course and BME 178.

Credits

5

Requirements

Enrollment is restricted to graduate students in PBSE program (Program in Biomedical Science and Engineering: Biomolecular Engineering and Bioinformatics (BMEB), Microbial Biology and Pathogenesis (MICRO), Chemical Biology, Biochemistry and Biophysics (CB3), Molecular, Cell and Developmental Biology (MCDB)) or consent of instructor.

BME 280B Seminar on Bioinformatics and Bioengineering

Weekly seminar series covering topics of current research in computational biology, and bioinformatics. Current research work and literature in these areas are discussed. Short papers reflecting on presentations required. Available for Satisfactory/Unsatisfactory (or Pass/No Pass) grading only.

Credits

2

Repeatable for credit

Yes

BME 281A Seminar on Processive Enzymes and Nanopores

Weekly seminar series covering experimental research in nanopore technology and single-molecule analysis of polymerase function. Current research work and literature is discussed. Students lead some discussions and participate in all meetings.

Credits

2

Requirements

Enrollment is restricted to graduate students. Qualified undergraduates may enroll with permission of instructor.

Repeatable for credit

Yes

BME 281C Seminar in Cancer Genomics

Presents current computational biology research to identify genomics-based signatures of cancer onset, progression, and treatment response. Examples of such investigations include: genetic pathway interpretation of multivariate high-throughput datasets; discovery of mutations in whole-genome sequence; identifications and quantification of gene isoforms, alleles, and copy number variants; and machine-learning tools to predict clinical outcomes. Students present their own research, host journal clubs, and attend lectures and teleconferences to learn about research conducted by national and international projects.

Credits

2

Requirements

Enrollment is restricted to graduate students.

Repeatable for credit

Yes

BME 281D Seminar on Protein Engineering

Weekly seminar series covering experimental research in protein structure, function, and engineering. Current research work and literature in this area are discussed. Students lead some discussions and participate in all meetings.

Credits

2

Requirements

Enrollment is restricted to graduate students.

Repeatable for credit

Yes

BME 281E Seminar in Genomics

Current topics in genomics including high-throughput sequencing, genome assembly, and comparative genomics. Students design and implement independent research projects. Weekly laboratory meetings are held to discuss these projects and related research in the field.

Credits

2

Requirements

Enrollment is restricted to graduate students

Repeatable for credit

Yes

BME 281F Blood Cell Development

Weekly seminar covering topics in current research on blood cell development and stem cell biology. Current research and literature in these areas discussed. Students lead some discussions and participate in all meetings.

Credits

2

Requirements

Enrollment is restricted to graduate students. Undergraduates may enroll with permission of instructor.

Repeatable for credit

Yes

BME 281G Seminar on Cell Fate Decisions

Weekly seminar series covering experimental research in cell fate decisions. Current research work and literature in this area is discussed. Students lead some discussions and participate in all meetings. Available for Satisfactory/Unsatisfactory or Pass/No Pass grading only.

Credits

2

Requirements

Enrollment is restricted to graduate students only; qualified undergraduate students may enroll with permission of the instructor.

Repeatable for credit

Yes

BME 281H Live Cell Biotechnology Seminar

Weekly seminar series covering topics of current computational and experimental research in live cell biotechnology. Current research work and literature in this area are discussed. Students lead some discussions and participate in all meetings. (Formerly offered as Seminar in Comparative Genomics.)

Credits

2

Requirements

Enrollment is restricted to graduate students; qualified undergraduates may enroll with permission of instructor.

Repeatable for credit

Yes

BME 281J Seminar in Computational Genomics and Biomedicine

Research seminar of the UCSC Computational Genomic Laboratory and Platform Teams. Students receive hands-on instruction in modern computational methods to address research questions. Topics include: genomic and transcriptomic sequence analysis methods, comparative and evolutionary genomics, big-data genomic analysis, biomedical data sharing, and precision medicine. Students attend and participate in monthly lab meetings, monthly all-hands meetings, where students give a quick report on their progress and the next month's goals, and a bi-weekly journal club, where pairs of students present and discuss a paper of their choosing with the lab. Students also participate in hands-on, active computational laboratory-based research. Student evaluation is based on suitable progress toward research goals and graduate program progress.

Credits

2

Requirements

Enrollment is restricted to graduate students.

Repeatable for credit

Yes

BME 281L Seminar in Computational Genetics

Weekly seminar series covering topics and experimental research in computational genetics. Current research work and literature in this area discussed. Students lead some discussions and participate in all meetings.

Credits

2

Requirements

Enrollment is restricted to graduate students; qualified undergraduates may enroll with permission of instructor.

Repeatable for credit

Yes

BME 281M Seminar on Chromosome Biology and Function

Weekly seminar series covering experimental research in chromosome structure and repeat biology. Current research work and literature in this area is discussed. Students lead some discussions and participate in all meetings. Available for Satisfactory/Unsatisfactory or Pass/No Pass grading only.

Credits

2

Requirements

Enrollment is restricted to graduate students. Qualified undergraduates may enroll with permission of instructor.

Repeatable for credit

Yes

BME 281N Seminar in Transcriptomics

Covers current topics in computational and experimental research in transcriptomics. Current research work and literature discussed. Weekly laboratory meetings held to discuss these projects and related research in the field.

Credits

2

Requirements

Enrollment is restricted to graduate students.

Repeatable for credit

Yes

BME 281P Seminar on Nanotechnology and Biosensors

Weekly seminar covering topics of research in the development of new tools and technologies to detect and study genes and proteins. Latest research work and literature in these areas are discussed. Students lead some discussions and participate in all meetings.

Credits

2

Requirements

Enrollment is restricted to graduate students; qualified undergraduates may enroll with permission of instructor.

Repeatable for credit

Yes

BME 281R Seminar in Stem Cell Genomics

Weekly seminar series covering topics in research on stem cell genomics. Current research and literature in this area is discussed. Students lead some discussions and participate in all meetings.

Credits

2

Requirements

Enrollment restricted to graduate students; qualified undergraduates may enroll with instructor permission.

BME 281S Seminar in Computational Functional Genomics

Weekly seminar series covering topics of current computational and experimental research in computational functional genomics. Current research work and literature in this area discussed. Students lead some discussions and participate in all meetings.

Credits

2

Requirements

Enrollment is restricted to graduate students; qualified undergraduates may enroll with permission of instructor.

Repeatable for credit

Yes

BME 281T Seminar in Neuroengineering and Systems Neuroscience

Discusses research topics in 3D stem cell-derived brain organoid models, neuroengineering and systems neuroscience. Students lead some discussions and participate in all meetings. Available for Satisfactory/Unsatisfactory or Pass/No Pass grading only. Enrollment is restricted to graduate students; qualified undergraduate students may enroll with permission of the instructor.

Credits

2

Requirements

Enrollment is restricted to graduate students.

Repeatable for credit

Yes

BME 281V Immunogenomics Seminar

Journal club and research presentations in immunogenomics. Enrollment is by consent of the instructor and is restricted to graduate students, juniors, and seniors.

Credits

2

Repeatable for credit

Yes

BME 281X Microbial Symbiosis

Seminar course consisting of the Russell Lab's weekly meeting to cover lab business, present and discuss new results, practice presentations, and read recent scientific literature. May be repeated for credit. Enrollment is restricted to graduate students and is by permission of the instructor.

Credits

2

Repeatable for credit

Yes

BME 281Y Seminar on Protein Design

Includes the Yeh Lab’s weekly group meeting to discuss new data, present research paper, pitch new scientific idea, cover lab business, and practice presentations. Available for Satisfactory/Unsatisfactory or Pass/No Pass grading only.

Credits

2

Requirements

Enrollment is restricted to graduate students only; qualified undergraduate students may enroll with permission of the instructor.

Repeatable for credit

Yes

BME 281Z Seminar in Population and Evolutionary Genomics

Covers major recent topics in evolutionary and population genomics. Consists primarily of discussions of recent literature and updates on group members' research. Enrollment is available only to members of the Corbett-Detig laboratory.

Credits

2

Repeatable for credit

Yes

BME 293 Seminar in Biomolecular Engineering

Weekly seminar series covering topics of bioinformatics and biomolecular engineering research. Current research work and literature in this area discussed. Students lead some discussions and participate in all meetings.

Credits

5

Requirements

Enrollment is restricted to graduate students; qualified undergraduates may enroll with permission of instructor.

BME 296 Research in Bioinformatics

Independent research in bioinformatics under faculty supervision. Although this course may be repeated for credit, not every degree program accepts a repeated course toward degree requirements. Students submit petition to sponsoring agency.

Credits

5

Repeatable for credit

Yes

BME 297A Independent Study or Research

Independent study or research under faculty supervision. Although course may be repeated for credit, not every degree program accepts a repeated course toward degree requirements. Students submit petition to sponsoring agency.

Credits

5

Repeatable for credit

Yes

BME 297B Independent Study or Research

Independent study or research under faculty supervision. Although course may be repeated for credit, not every degree program accepts a repeated course toward degree requirements. Students submit petition to sponsoring agency.

Credits

10

Repeatable for credit

Yes

BME 297C Independent Study or Research

Independent study or research under faculty supervision. Although course may be repeated for credit, not every degree program accepts a repeated course toward degree requirements. Students submit petition to sponsoring agency.

Credits

15

Repeatable for credit

Yes

BME 297F Independent Study or Research

Independent study or research under faculty supervision. Although course may be repeated for credit, not every degree program accepts a repeated course toward degree requirements. Students submit petition to sponsoring agency. Enrollment is restricted to graduate students.

Credits

2

Repeatable for credit

Yes

BME 299A Thesis Research

Thesis research conducted under faculty supervision. Although course may be repeated for credit, not every degree program accepts a repeated course towards degree requirements.Students submit petition to sponsoring agency.

Credits

5

Repeatable for credit

Yes

BME 299B Thesis Research

Thesis research conducted under faculty supervision. Although course may be repeated for credit, not every degree program accepts a repeated course towards degree requirements.Students submit petition to sponsoring agency.

Credits

10

Repeatable for credit

Yes

BME 299C Thesis Research

Thesis research conducted under faculty supervision. Although course may be repeated for credit, not every degree program accepts a repeated course towards degree requirements.Students submit petition to sponsoring agency.

Credits

15

Repeatable for credit

Yes

Cross-listed courses that are managed by another department are listed at the bottom.

Cross-listed Courses

BIOL 247 Stem Cell Research: Scientific, Ethical, Social, and Legal Issues

Investigates the scientific, ethical, social, and legal dimensions of human embryonic stem-cell research, including the moral status of the embryo; the concept of respect for life; ethical constraints on oocyte procurement; creation of embryonic chimeras; federal policies; and political realities. (Also offered as Biomolecular Engineering 247. Students cannot receive credit for both courses.) Prerequisite(s): Course in stem cell biology (ex: BME 278 Stem Cell Research) or the equivalent knowledge. Enrollment is restricted to graduate students.

Credits

2

Cross Listed Courses

BME 247

Instructor

Lindsay Hinck

Requirements

Prerequisite(s): Course in stem cell biology (ex: BME 278 Stem Cell Research) or the equivalent knowledge. Enrollment is restricted to graduate students.

SOCY 268A Science and Justice: Experiments in Collaboration

Considers the practical and epistemological necessity of collaborative research in the development of new sciences and technologies that are attentive to questions of ethics and justice. Enrollment is by permission of instructor. Enrollment is restricted to graduate students.

Credits

5

Cross Listed Courses

BME 268A, FMST 268A, CRES 268A

SOCY 268B Science and Justice Research Seminar

Provides in-depth instruction in conducting collaborative interdisciplinary research. Students produce a final research project that explores how this training might generate research that is more responsive to the links between questions of knowledge and questions of justice. Prerequisite(s): SOCY 268A, BME 268A, FMST 268A, or ANTH 267A. Enrollment is restricted to graduate students and by permission of the instructor.

Credits

5

Cross Listed Courses

FMST 268B, BME 268B, ANTH 267B