500

BMS 501 Foundations in Life Sciences

Explore the dynamics of gene expression at the level of DNA, RNA and protein. Develop ability to link techniques in molecular biology with appropriate applications in explaining the scientific approach to gene analysis.

Credits

3.0

Cross Listed Courses

Also offered as BIFX 501

Offered

Fall Semester

BMS 511 Protein Biochemistry

Prerequisites: Two semesters of organic chemistry. A study of the structure and function of biological macromolecules, particularly proteins. Topics include acid-base equilibria, protein folding, enzyme catalysis, allosterism and protein engineering.

Credits

3.0

Cross Listed Courses

Double-numbered course; offered with undergraduate-level BIOL 411

Offered

Fall Semester

BMS 512 Biochemistry of Intermediary Metabolism

Prerequisite: Two semesters of organic chemistry. A study of the generation and storage of metabolic energy and of the structure, biosynthesis and function of nucleic acids.

Credits

3.0

Cross Listed Courses

Double-numbered course; offered with undergraduate-level BIOL 412

Offered

As Needed

BMS 520 Protein Purification and Characterization

Prerequisite: BMS 511/411. Lab fee. A lecture/lab course addressing the principles and practical aspects of protein purification and characterization. In addition, the course will cover practical aspects of enzymology, including kinetic analysis of enzyme-catalyzed reactions.

Credits

3.0

Offered

Summer Semester

BMS 523 Cell Structure & Function

Prerequisites: Organic Chemistry and Cell Biology. A study of the structure of cellular organelles and the biochemistry of cellular events, including signal transduction, transport, protein synthesis, respiration, secretion and tissue organizations. Emphasis is given to experimental designs used in analyzing cellular structures and/or functions.

Credits

3.0

Offered

Fall Semester

BMS 524 Molecular Biology of Eukaryotic Cells

Prerequisite: Genetics course. The molecular biology of gene expression in eukaryotic cells. Topics include gene mapping, diagnostic screening for genetic anomalies, molecular cloning and genetic regulatory mechanisms. Emphasis on current experimental techniques used to map genes and understand gene expression.

Credits

3.0

Cross Listed Courses

Double-numbered course; offered with undergraduate-level BIOL 424

Offered

Spring Semester (Even Years)

BMS 525 Virology

Prerequisites: BMS 523 and BMS 512. An introduction to animal viruses with emphasis on classification, structure, the molecular biology of replication and biological activity within eukaryotic cells.

Credits

3.0

Cross Listed Courses

Double-numbered course; offered with undergraduate-level BIOL 425

Offered

Fall Semester

BMS 527 Pathogenic Microbiology

Lab fee. The biology of microorganisms including morphological, biochemical, genetic, pathogenic and antigenic attributes, with special emphasis on experimental and theoretical aspects of the mechanisms of pathogenicity and virulence.

Credits

3.0

Offered

As Needed

BMS 528 Immunology

Prerequisite: BMS 523. Theories and mechanism of the immune response, including structure and function of immunoglobulins, antigen-antibody reactions, immunobiology, immunogenetics, immuno-logic enhancement, immunologic protection, immunologic injury, humoral and cell mediated immunity and experimental methods of analysis of antigen-antibody reactions.

Credits

3.0

Cross Listed Courses

Double-numbered course; offered with undergraduate-level BIOL 428

Offered

Fall Semester

BMS 529 Oncology Drug Discovery

Prerequisites: BMS 511, BMS 523, BMS 524, BMS 537 or Permission of Instructor

This course will teach you the basics of modern drug discovery efforts to target human cancers. Students will survey the tools and techniques used for cutting-edge targeted cancer therapies and explore some of the major successes and failures of oncology drug discovery. Students will have an understanding of the process of drug discovery from target identification, through assay development, compound screening, and entry into the clinic, as well as a better idea of the complexity of the process and the many failure modes experienced.

Credits

3.0

Offered

Fall Semester (Even Years)

BMS 533 Medical Virology

Prerequisite: BMS 525. The role of viruses in human infectious diseases and tumor formation; the host response to viral infection and the epidemiology of viral diseases.

Credits

3.0

Offered

Fall Semester (Even Years)

BMS 534 Basic Principles & Methods in Molecular Genetics

Prerequisites: BMS 524 or permission of the instructor. Lab fee. This integrated lab-lecture course provides basic concepts and hands-on experience with common molecular genetics and recombinant DNA methods. Topics include techniques for the isolation of DNA and RNA, gene cloning employing plasmid vectors, DNA sequencing, polymerase chain reaction (PCR) technology, expression of fusion proteins in E. coli, and web-based analysis of sequence data.

Credits

3.0

Cross Listed Courses

Double-numbered course; offered with undergraduate-level BIOL 434

Offered

As Needed

BMS 535 Advanced Topics in Recombinant DNA Technology: Gene Transfer, Expression, and Detection

Prerequisite: BMS 534 or permission of the instructor. Lab fee. A study of the theory and techniques for the introduction, expression and detection of macromolecules in eukaryotic cells. The topics to be covered include the introduction of recombinant genes in eukaryotic hosts. Methodologies to produce transgenic animals will be discussed. Analysis of eukaryotic gene expression, detection of activity by western analysis and cell-based assays

Credits

3.0

Offered

Summer Semester (As Needed)

BMS 537 Introduction to Bioinformatics

Prerequisites: BMS 511 and BMS 524 or permission of the instructor. Lab fee. This is a hands-on, applied course that will introduce students to the use of computer software and Web servers in the analysis of biological sequence data (DNA and protein). Topics include: Pairwise and multiple sequence alignment, BLAST, scoring matrices, phylogenetic analysis, DNA sequence analysis and prediction of 2-D and 3-D molecular structures.

Credits

3.0

Cross Listed Courses

Double-numbered course; offered with undergraduate-level BIOL 437

Offered

Spring Semester

BMS 539 Molecular Immunology

Prerequisite: BMS 528. Lab fee. This combined lecture and laboratory course discusses Ig gene assembly, rearrangements, regulation and expression; T-cell receptors; antigen processing; and advances in antibody engineering. The laboratory exercises cover techniques such as ELISA, immunoblot, hybridoma preparation and evaluation, immunoaffinity chromatography and phage display of antibody fragments.

Credits

3.0

Offered

As Needed

BMS 540 Advanced Topics in Recombinant DNA Technology: Genome Analysis & Mapping

Prerequisite: BMS 534 or permission of the instructor. Lab fee. A study of the techniques used in the cloning, analysis and mapping of genomic DNA. Topics include cloning with cosmid, P1 and YAC vectors, techniques used in linkage analysis and the direct detection of genomic polymorphisms, and strategies to prepare genetic and physical maps. The impact of the combined use of genetic and physical maps in biomedicine will be discussed.

Credits

3.0

Offered

Fall Semester (Odd Years)

BMS 541 Advanced Topics in Recombinant DNA Technology: Gene Structure & Function

Prerequisite: BMS 534 or permission of the instructor. Lab fee. A study of advanced topics in recombinant DNA technology including high resolution mapping of RNA, nucleic acid-protein interactions, current methodologies for DNA sequence analysis and mutagensis strategies. The impact of these recombinant DNA techniques on developments in biomedicine will be discussed.

Credits

3.0

Offered

Spring Semester (Even Years)

BMS 542 Ethics in Science

The course considers the ethical dilemmas one could face in a career in science, including how information gained in the research lab is conveyed to the wider scientific audience. Topics included are the peer review process, the patent process, the Recombinant DNA Advisory Committee, the FDA’s role in drug approval, the funding of research and the national research prioritization process.

Credits

3.0

Offered

Summer Semester (As Needed)

BMS 543 Advanced Immunology

Prerequisite: BMS 528 or permission of the instructor. A seminar course offering an in-depth investigation of a prescribed area of immunology. Past topics have dealt with AIDS/HIV, cancer and intracellular signaling, all emphasizing the role of the immune response. Emphasis is placed on the use of current literature to develop a thorough understanding of recent advances.

Credits

3.0

Offered

Spring Semester (Even Years)

BMS 544 Good Laboratory Practices: A Practical Approach

Prerequisite: Open to students with a declared concentration in Regulatory Compliance, or permission of the instructor. The course is designed to provide a practical knowledge and understanding of Good Laboratory Practice (GLP) regulations with examples useful to laboratory workers, study directors and management. The course will address the current interpretation of the code of federal regulations (21CFR58) and the International Committee on Harmonization (ICH).

Credits

3.0

Offered

As Needed

BMS 545 Product Development

Prerequisites: Open to students with a declared concentration in Regulatory Compliance, or permission of the instructor. The course provides an overview of the regulatory process for new biologics, drug and device development. Emphasis is on a strategic development approach and good science standards to ensure safe and effective new therapies for prevention and treatment of disease.

Credits

3.0

Offered

Fall Semester (Odd Years)

BMS 546 Good Manufacturing Practices

Prerequisites: Open to students with a declared concentration in Regulatory Compliance, or permission of the instructor. This course will provide an in-depth review of current good manufacturing practice regulations promulgated by the Food and Drug Administration (FDA) in their regulation of the drug and device industries. Recent FDA regulatory compliance experience regarding the application of the GMP regulations, including areas where industry has failed to correctly apply or interpret current GMPs will also be examined.

Credits

3.0

Offered

Spring Semester (Even Years)

BMS 548 Good Clinical Practice

Prerequisites: Open to students with a declared concentration in Regulatory Compliance, or permission of the instructor. This course provides a detailed explanation of the guidelines that should be followed when generating clinical data that are intended to be submitted to the Food and Drug Administration in support of a product license. The principles of clinical trial conduct and design can be applied to any investigation involving human subjects.

Credits

3.0

Offered

Spring Semester (Even Years)

BMS 549 Regulation of Medical Devices

Prerequisites: BMS 545 and BMS 547. This course offers an overview of the historical development as well as the current status of the laws, regulations and guidelines governing medical devices. Key aspects of gaining regulatory approval for all classes of medical devices using various submission processes including the 510(k) Premarket Notification, the Premarket Approval Application and the Product Development Protocol are examined.

Credits

3.0

Offered

Spring Semester (Even Years)

BMS 552 Biomedical Literature Review

Prerequisites: BMS 511, BMS 523, BMS 524 and BMS 537 or permission of instructor

This course is recommended for students planning to take BMS 571 and provides students more exposure and experience with reading primary literature.  Discussions and presentations on the experimental approaches, techniques, analysis, and future directions will be critical to students' understanding of the literature.  Completion of this course prior to the capstone is strongly encouraged.

Credits

3.0

Offered

Summer Semester

BMS 571 Biomedical Science Seminar

Prerequisite: BMS 511, BMS 523, BMS 524, BMS 537 and Completion of 21 credits of coursework in the BMS program with a 3.0 GPA average, or permission of the instructor. 

Students will choose a specific research problem to address in a grant proposal document.  The scientific merit of the proposal will be presented to the faculty.

Credits

3.0

Offered

Both Semesters

BMS 575 Independent Study

Prerequisite: permission of the chair of the department. A maximum of 6 credits may be applied to a degree program. (1-3 credits per independent study) Reading and/or research in a selected field. An approved title for the independent study must be submitted with the registration forms. 

Credits

1.0 - 3.0

Offered

Either Semester

BMS 580A Biomedical Science Thesis A

Supervision of the master’s thesis. Required of all degree candidates who select the thesis option.

Credits

3.0

Offered

Either Semester

BMS 580B Biomedical Science Thesis B

Prerequisite: BMS 580A

Completion of the master’s thesis. Required of all degree candidates who select the thesis option. 

Credits

3.0

Offered

Either Semester

BMS 590 Advanced Topics in Biomedical Techniques

Prerequisite: Permission of the instructor. May require a lab fee. A practical course in newer topics, methods and/or instrumentation used in biomedical research. The course is intended not only for graduate students but also for investigators who are interested in learning about topics outside of their own field that can be useful in their research. This can be a lab/lecture or lecture only class, dependent on the topic to be presented.

Credits

3.0

Offered

As Needed

BMS 597 Internship

Prerequisites: Permission of Faculty. Practical training relevant to student's course of study at an approved worksite. Eligible students must have completed at least 18 credits have a 3.25 cumulative GPA or higher. Worksite and project must be approved by BMS Program Director and BMS faculty. A maximum of 3 credits may be applied to a degree program. This course is graded on a satisfactory/unsatisfactory basis.

Credits

1.0-3.0

Offered

Both Semesters